mitochondrial membrane potential

2002
Dykens, J.A., Fleck, B., Ghosh, S., Lewis, M., Velicelebi, G., and Ward, M.W. (2002). “High-throughput assessment of mitochondrial membrane potential in situ using flourescense resonance energy transfer.” Mitochondrion 1:461-473.

Terkeltaub, R., Johnson, K., Murphy, A., and Ghosh, S. (2002). Invited Review: “The mitochondrion in osteoarthritis” Mitochondrion 1:301-379.

Herrnstadt, C., Preston, G., Andrews, R., Chinnery, P., Lightowlers, R.N., Turnbull, D.M., Kubacka, I., and Howell, N. (2002). “A high frequency of mtDNA polymorphisms in HeLa cell sublines.” Mutations Research 501:19-28.

Herrnstadt, C., Elson, J.L., Fahy, E., Preston, G., Turnbull, D.M., Anderson, C., Ghosh, S.S., Olefsky, J.M., Beal, M.F., Davis, R.E., Howell, N. (2002). “Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups.” American Journal of Human Genetics 70:1152-1171, 2002.

2001
Scheffler, N.K., Miller, S.W., Carroll, A.K., Anderson, C.M., Davis, R.E., Ghosh, S.S., Gibson, B.W. (2001). “Two-dimensional Electrophoresis and Mass Spectrometric Identification of Mitochondrial Proteins from an SH-SY5Y Neuroblastoma Cell Line.” Mitochondrion 1:161-179.

Tomaselli, K., and Moos, W. (2001) “Cell Death as a Life Force.” Drug Development Research 52:505-507.

Howell, N., Herrnstadt, C., Mackey, D. (2001) “Different Patterns of Expansion/Contraction During the Evolution of an mtDNA Simple Repeat.” Molecular Biology and Evolution 18(8)1593-1596.

Dykens, J.A. 2001. “Synopsis of Non-Invasive Assessments and Therapeutic Intervention Presentations at 2nd International Conference on Oxidative Stress and Aging”, IDrugs 7: 767-770.

Dykens, J.A., Stout A.K. 2001. “Fluorescent Dyes and Assessment of Mitochondrial Membrane Potential in FRET Modes.” Methods in Cell Biology 65: 285-309.

2000
Johnson, K., Jung, A., Murphy, A., Andreyev, A., Dykens, J., Terkeltaub, R. (2000) “Mitochondrial Oxidative Phosphorylation is a Downstream Regulator of Nitric Oxide Effects on Chondrocyte Matrix Synthesis and Mineralization.” Arthritis and Rheumatism 43(7):1560-1570.

Moos, W., Steliou, K. (2000) “Pharmacogenomics 2000”
Drug Development Research 49:1-3.

Howell, N., Ghosh, S.S., Fahy, E. and Bindoff, L. (2000). Longitudinal analysis of the segregation of mtDNA mutations in heteroplasmic individuals.
J. Neurological Sciences 172:1-6

Kadens, D.T. and Le Gear, M.L. (2000). Pharmacogenomics: Into the New Millenium Drug Development Research 49:17-21.

1999
Murphy, A.N., and Fiskum, G. (1999). Bcl-2 and Ca2+-Mediated Mitochondrial Dysfunction in Neural Cell Death. Biochemical Society Transactions 66:33-41

Davis, R. E. (1999). “ALzheimer’s disease: Can we treat it?” Current Opinion in Central & Peripheral Nervous System 1(3):322-324.

Ghosh, S.S.,Swerdlow, R. H.,Miller, S.W., Sheeman, B.,Parker, W. D. and Davis, R. E.(1999). Use of Cytoplasmic Hybrid Cell Lines for Elucidating the role of Mitochondrial Dysfunction in Alzheimer’s Disease and Parkinson’s Disease Annals of the New York Academy of Sciences 893:176-191.

Herrnstadt, C., Clevenger, W., Ghosh, S.S., Anderson, C., Fahy, E., Miller, S., Howell, N., and Davis, R.E. (1999). A Novel Mitochondrial DNA-like Sequence in the Human Nuclear Genome. Genomics 60:67-77.

Anderson, C. M. (1999). Mitochondrial Dysfunction in Diabetes Mellitus. Drug Development Research 46:67-79.

Dykens, J. A., Davis, R. E., and Moos, W. H. (1999). Introduction to Mitochondrial Function and Genomics. Drug Development Research 46:2-13.

Fiskum, G., Murphy, A. N., and Beal, F. M. (1999). Mitochondria in Neurodegeneration: Acute Ischemia and Chronic Neurodegenerative Diseases. Journal of Cerebral Blood Flow & Metabolism 19:351-369.

Murphy, A. N. (1999). Potential Mechanisms of Mitochondrial Cytochrome-c Release During Apoptosis. Drug Development Research 46:18-25.

Murphy, A. N., Fiskum, G., and Beal, F. M. (1999). Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death. Journal of Cerebral Blood Flow & Metabolism 19:231-245.

Moos, W.H., Dykens, J. A. & Davis, R.E. (1999). It Was the Best of Mito Times: A Tale of Two Genomes. Pharmaceutical News 6:15-29.

Dykens, J. A. (1999). “Free Radicals and Mitochondrial Dysfunction in Excitotoxicity and Neurodegenerative Diseases” In: Cell Death and Diseases of the Nervous System (Koliatos, V. E. & Ratan, R. R., eds.), pp. 45-68. Humana Press, Totowa, New Jersey.

1998
Davis, R. E. & Moos, W. H. (1998). Mitochondrial Dysfunction in Alzheimer’s Disease. Alzheimer’s Review 7:160-163.

Dykens, J. A. & Baginski, T. (1998). Urinary 8-Hydroxydeoxyguanosine Excretion as a Non-Invasive Marker of Inflammation in Animal Models of Colitis and Crohn’s Disease. Scandinavian J. Gastroenterol. 33:628-636.

Ghosh, S. S., Miller, S., Herrnstadt, C., Fahy, E., Shinbou, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N., Parker, W. D. & Davis, R. E. (1998). “Mitochondrial Dysfunction and Alzheimer’s Disease” In: Progress in Alzheimer’s and Parkinson’s Diseases (Fisher, A., Hanin, I. & Yoshida, M., eds.), Vol. 49, pp. 59-66. Plenum Press, New York.

Moos, W. H. & Davis, R. E. (1998). Stages of a Scientific Revolution: Isn’t It Funny How Truisms Come and Go? Pharmaceutical News 5:38-39.

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, J. N., Trimmer, P. A., Tuttle, J. B., Bennett, J. P., Wooten, G. F., Davis, R. E. & Parker, W. D. (1998). “Mitochondrial Dysfunction in Parkinson’s Disease: Potential Applications for Cybrid Modeling of the Disease” In: Progress in Alzheimer’s and Parkinson’s Diseases (Fisher, A., Hanin, I. & Yoshida, M., eds.), Vol. 49, pp. 67-75. Plenum Press, New York.

Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Trimmer, P. A., Miller, S. W., Maguire, D. J., Sheehan, J. P., Maguire, R. S., Pattee, G., Juel, V. C., Phillips, L. H., Tuttle, J. B., Bennett, J. P., Davis, R. E. & Parker, W. D. (1998). Mitochondria in Sporadic Amyotrophic Lateral Sclerosis. Exp. Neurol. 153:135-142.

Tecle, H., Barrett, S. D., Lauffer, D. J., Augelli-Szafran, C., Brann, M. R., Callahan, M. J., Caprathe, B. W., Davis, R. E., Doyle, P. D., Eubanks, D., Lipiniski, W., Mirzadegan, T., Moos, W. H., Moreland, D. W., Nelson, C. B., Pavia, M. R., Raby, C., Schwarz, R. D., Spencer, C. J., Thomas, A. J. & Jaen, J. C. (1998). Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3′-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist. J. Med. Chem. 41:2524-2536.

1997
Cassarino, D., Fall, C. P., Swerdlow, R. H., Smith, T. S., Halvorsen, E. M., Miller, S. W., Parks, J. P., Parker, W. D. & Bennett, J. P. (1997). Elevated Reactive Oxygen Species and Antioxidant Enzyme Activities in Animal and Cellular Models of Parkinson’s Disease. Biochmica et Biophysica Acta 1362:77-86.

Davis, R. E., Miller, S. W., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinbou, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N. & Parker, W. D. (1997). Mutations in Mitochondrial Cytochrome Oxidase Genes Segregate with Late Onset Alzheimer’s Disease. Proceedings of the National Academy of Sciences (U.S.A.) 94:4526-4531.

Dykens, J. A. (1997). “Mitochondrial Free Radical Production and Oxidative Pathophysiology: Implications for Neurodegenerative Disease” In: Mitochondria & Free Radicals in Neurodegenerative Diseases (Beal, M. F., Howell, N. & Bodis- Wollner, I., eds.), pp. 29-55. Wiley-Liss, Inc., New York.

Fahy, E., Nazarbaghi, R., Zomorrodi, M., Herrnstadt, C., D., P. W., Davis, R. E. & Ghosh, S. S. (1997). Multiplex Fluorescence-Based Primer Extension Method for Quantitative Mutation Analysis of Mitochondrial DNA and Its Diagnostic Application for Alzheimer’s Disease. Nucleic Acids Research 25:3102-3109.

Parker, W. D. & Davis, R. E. (1997). “Primary Mitochondrial DNA Defects as a Causative Event in Alzheimer’s Disease” In: Mitochondria & Free Radicals in Neurodegenerative Diseases (Beal, M. F., Howell, N. & Bodis-Wollner, I., eds.), pp. 319-333. Wiley-Liss, Inc., New York.

Schimmer, R. C., Schrier, D. J., Flory, C. M., Schimmer, B. B., Dykens, J. A., Tung, D., Jacobson, P. B., Friedel, H. P., Conroy, M. C. & Ward, P. A. (1997). Streptoccal Cell Wall-Induced Arthritis: Requirements for Neutrophils, P-selectin, ICAM-1 and MIP-2. Journal of Immunology 159:4103-4108.

Sheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D. & Tuttle, J. B. (1997). Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease. The Journal of Neuroscience 17:4612-4622.

Sheehan, J. P., Swerdlow, R. H., Parker, W. D., Miller, S. W., Davis, R. E. & Tuttle, J. B. (1997). Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson’s Disease. Journal of Neurochemistry 68:1221-1233.

Swerdlow, R. H., Parks, J. K., Cassarino, B. S., Maguire, D. J., Maguire, R. S., Bennett, J. P., Davis, R. E. & Parker, W. D. (1997). Cybrids in Alzheimer’s Disease: A Cellular Model of the Disease? Neurology 49:918-925.

Williams, M. & Davis, R. E. (1997). Alzheimer’s Disease and Related Dementias: Prospects for Treatment. Expert Opinion on Investigational Drugs 6:735-757.

1996
Dykens, J. A., Wiseman, R. W. & Hardin, C. D. (1996). Phosphotransferase Function is Conserved During Hypoxia-Reoxygenation Despite Loss of Enzyme Activity. J. Comparative Physiology 166:359-368.

Ghosh, S. S., Dakoji, S., Tanaka, Y., Cho, Y. J. & Mobashery, M. (1996).w Properties of Analogs of an Intermediate in the Process of Mechanism-Based Inactivation of Carboxypeptidase A. Bioorganic & Medicinal Chemistry 4:1487- 1492.

Ghosh, S. S., Fahy, E., Bodis-Wollner, J., Sherman, J. & Howell, N. (1996). Longitudinal Study of a Heteroplasmic 3460 Leber Optic Neuropathy Family by Multiplexed Primer-Extension Analysis and Nucleotide Sequencing. Am. J. Human. Gen. 58:325-334.

Miller, S. W., Trimmer, P. A., Parker, W. D. & Davis, R. E. (1996). Creation and Characterization of Mitochondrial DNA-Depleted Cell Lines with “Neuronal-Like” Properties. Journal of Neurochemistry 67:1897-1907.

Swerdlow, R. H., Parks, J. K., Miller, S. W., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., Davis, R. E. & Parker, W. D. (1996). Origin and Functional Consequences of the Complex I Defect in Parkinson’s Disease. Annals of Neurology 40:663-671.

Williams, M. & Davis, R. E. (1996). Alzheimer’s Disease and Related Dementias: Prospects for Treatment. Emerging Drugs: The Prospects for Improved Medicine 7:125-154.

1995
Davis, R. E., Doyle, P. D., Carroll, R. T., Emmerling, M. R. & Jaen, J. (1995). Cholinergic Therapies for Alzheimer’s Disease: Palliative or Disease Altering? Arzneimittelforschung 45:425-431.

Ghosh, S. S., Fahy, E. & Gingeras, T. R. (1995). “The Self-Sustained Sequence Replication Reaction and Its Application in Clinical Diagnostics and Molecular Biology” In: Molecular Methods for Virus Detection (Wiedbrauk, D. L. & Farkas, D. H., eds.), pp. 287-314. Academic Press, Inc., San Diego.

Gingeras, T. R., Biery, M., Goulden, M., Ghosh, S. S. & Fahy, E. (1995). “Optimization and Characterization of 3SR-Based Assays” In: PCR Primer: A Laboratory Manual (Dieffenbach, C. W. & Dveksler, G. S., eds.), pp. 653-666. Cold Spring Harbor Laboratory Press, New York.

1994
Yang, M., Ghosh, S. S. & Millar, D. P. (1994). Direct Measurement of Thermodynamic and Kinetic Parameters of DNA Triple Helix Formation by Fluorescence Spectroscopy. Biochemistry 33:15329-15337.